Poster Presentations

Autophagy P1 – P10

P1 – Rosa Bartolomeo
mTORC1 hyperactivation in lysosomal storage disorders blocks autophagosome-lysosome fusion by suppressing phosphoinositide production

P2 – Albrecht M. Clement
Receptor-mediated endocytosis 8 (RME8) is a modulator of autophagy

P3 – Ilse Dingjan
Lipid peroxidation promotes autophagy and antigen cross-presentation

P4 – Paolo Grumati
RTN3 regulates tubular endoplasmic reticulum turnover via selective autophagy

P5 – Sandra Kissing
The V-ATPase: In vivo analysis of its contribution to autophagosome function and mTORC1 signalling

P6 – Antonina J. Kruppa
Dual role of myosin VI in mitochondrial quality control

P7 – Marijn Kuijpers
Autophagy in neurons: implications for ER structure and function

P8 – Elena Muscolino
Murine cytomegalovirus recruits the retromer complex to promote NEMO degradation by autophagy

P9 – Vera Schmiedel
Protein-protein-interactions in the autophagy pathway

P10 – Katharina Schneider
Bassoon regulates presynaptic autophagy

Endocytosis P11 – P13

P11 – Charlotte M.J. Flynn
Cell-surface amounts of IL-6R and gp130 are differentially controlled by endocytosis and recycling in dependence upon their ligand IL-6

P12 – Zuzana Kadlecova
Watching Endocytosis Live in HD: Close-up on AP2

P13 – Daphne Montizaan
Are nanoparticles entering by known endocytic pathways?

Endosomes P14 – P19

P14 – Miriam Bäumers
Interaction Studies between the Tumour Suppressor Lgd and the ESCRT-III Component Shrub as well as their Human Orthologs

P15 – Jürgen Fritsch
Differential TNF-R1 signal transduction is regulated by its subcellular localization and post-translational modification by ubiquitination and palmitoylation of different proteins

P16 – Arthur A. Melo
Structural insights into the activation mechanism of dynamin-like EHD ATPases

P17 – Kristina Scheider
Detecting conformational changes of CHMP4B induced by the interaction with mammalian CC2D1 proteins via FRET

P18 – Christine Tibbe
Functional Analysis of the Interaction between Lethal (2) giant discs and the ESCRT-III Component Shrub

P19 – Melinde Wijers
WASH is a key component of the endosomal sorting machinery to sort and direct members of the low-density lipoprotein receptor (LDLR) family to the cell surface

Golgi P20 – P23

P20 -Maximilian Borgmeyer
A functional analysis of Golgi-Satellites in between ERGIC and retromer in neuronal dendrites

P21 – Stephan Grunwald
Towards an understanding of the N-terminal acetylation of the Golgi-associated small GTPase ARFRP1 (yArl3) by the NatC complex

P22 – Malte Klüssendorf
Functional relevance of the trans-Golgi associated protein PIST (protein interacting specifically with tc10) in the central nervous system

P23- Peter T.A. Linders
Syntaxin 5 is essential for ERGIC and Golgi apparatus assembly

Infection P24 – P34

P24 – Katherine S.H. Beckham
Structure of a mycobacterial type VII secretion system membrane complex

P25 – Tom Crosskey
Deciphering the role of ATPases in mycobacterial Type VII secretion

P26 – Jost Enninga
Infection-associated macropinosomes determine the intracellular niche of Shigella and Salmonella

P27 – Diana Freire
A novel mechanism of programmed cell death in M. tuberculosis by a TA toxin hydrolyzing intracellular NAD

P28 – Ernst Jonscher
A Screen for Proteins involved in host cell cytosol uptake of Plasmodium falciparum blood stages

P29 – Matthias Klose
Intracellular processing of Borrelia burgdorferi by sorting nexins and RabGTPases in primary human macrophages

P30 – Susan Lassen
Perilipin-2 Regulates Lipid Droplet Morphology and Hepatitis C Virus Replication

P31 – Luise Linsenmeier
“I shall be released”: Mechanistic insights into the proteolytic shedding of the cellular prion protein

P32 – Tamara Pečenková
Subcellular Localization of Arabidopsis Pathogenesis-Related 1 (PR1) Protein

P33 – Maren Rudolph
Role of the Rho GTP binding protein TC10 in Staphylococcus aureus invasion of endothelial cells

P34 – Stefan Schille
Analyses of Leishmania-containing compartments identify novel receptors for LC3-associated phagocytosis

Lysosomes P35 – P54

P35 – Poorna Manasa Bhamidimarri
Lysosomal enzyme targeting in Hydra vulgaris, a Cnidarian (lower invertebrate)

P36 – Anja Capell
Loss of Progranulin leads to enhanced lysosomal activity in brain and fibroblasts from Grn-/- mice

P37 – Tatyana Danyukova
The role of CLN7 in dysregulation of soluble lysosomal proteins in cell-based models for CLN7 disease

P38 – Kate Densley
Characterising the binding partners of the lysosomal protein Mon1b

P39 – Giorgia Di Lorenzo
Role of the gamma-subunit of GlcNAc-1-phosphotransferase for selective mannose 6-phosphate formation on lysosomal enzymes

P40 – Adriana González
The Alzheimer´s disease risk factor Phospholipase D3 (PLD3) utilizes an ESCRT – and protease – dependent route to lysosomes

P41 – Saskia Heybrock
Role of the Lysosomal Integral Membrane Protein Type 2 in lysosomal cholesterol transport

P42 – Edgar Kaade
Investigation of the lysosomal proteome in different nutrient conditions

P43 – Arne Linhorst
Processing and Sorting of Plbd2

P44 – Tania Lopez-Hernandez
Absence of astrocytic AP-2 disrupts intracellular sodium and calcium homeostasis and dysregulates glutamate uptake and lysosomal function

P45 – Adrien Pasquier
Lysosomal degradation of insulin granules promotes β-cell failure in type 2 diabetes

P46 – Daniel Pouly
Cystinosin is a component of the mTORC1 pathway

P47- Sönke Rudnik
Initial characterisation of the phosphatidylinositol(4,5)bisphosphat 4-phosphatase TMEM55A and TMEM55B

P48- Kristine Schauer
Systematic analysis of lysosome positioning changes downstream of different signaling pathways

P49- Carolin Schmidtke
Transcriptional control of lysosomal components in CLN3 defective cells

P50 – Miguel C. Seabra
Mechanisms of melanin transfer from melanocytes and formation of a parasol in keratinocytes

P51 – Reini van der Welle
Characterization of Vps41 mutations leading to a Parkinson-like neurodegenerative phenotype

P52 – Renata Voltolini Velho
Activation of GlcNAc-1-phosphotransferase by site-1 protease is required for trafficking of lysosomal enzymes

P53 – Lena Wartosch
The structure and function of the HOPS complex component VPS33A provide insights into a point mutation that causes a lysosomal storage disease

P54 – Georg Werner
Decreased expression of the FTLD associated transmembrane protein TMEM106B impairs lysosomal function

Membrane Fusion P55 – P60

P55 – Christian Bollmann
Neuronal phenotype in Vti1a-/-Vti1b-/- double knockout mice.

P56 – Niklas Krause
Characterization of the interaction between the neuronal protein α synuclein and the ER/Golgi SNARE GOSR2

P57 – Marli Morais Duarte
Mutations in the conserved SNARE-domain of GOSR2 influences the vesicular transport from ER to Golgi in HeLa cells

P58 – Jeffrey Noel
Toward understanding the mechano-chemical cycle of the dynamin motor

P59 – Simone Schmücker
Alterations in signaling of the TGF-β/BMP superfamily and cell migration contribute to bone malformation in Vti1a-/-Vti1b-/- double knockout mice

P60 –Christiane Wiegand
Phenotypic alterations in Vti1a-/-Vti1b-/- double knockout mice

Protein Quality Control P61 – P65

P61 – Maria Agthe
Mutations of the IL-11R which cause craniosynostosis in human patients influence receptor trafficking and maturation

P62 – Laylan Bramasole
UFD-2 E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

P63 – Irene Paolucci
Investigating secretion and extracellular toxicity of neuroserpin-polymers in FENIB

P64 – Anna T. Reinicke
Deubuiquitinating enzyme UCH-L1 promotes dendritic cell antigen cross presentation

P65 – Ankit Turakhiya
A novel, conserved function of the Cdc48 cofactor Cuz1 in arsenite stress response

Vesicular Transport P66 – P77

P66 – Maria Andres-Alonso
The RapGAP SPAR2/SIPA1L2 provides a ride-on service for TrkB endosomes and autophagosomes

P67 – Kirsten Bacia
Quantitation of coat protein binding to vesicles by dual-color fluorescence cross-correlation spectroscopy

P68 – Thierry Galli
The non-fusogenic Sec22b/Stx1 SNARE-complex operates with E-Syts at ER-PM contact sites in neurite growth

P69 – Stephan Kiontke
Mechanistic insights into the heterodimeric nucleotide exchange factor complex Mon1-Ccz1 and its human homolog BLOC-3

P70 – Julia D. Knopf
Regulation of secretion dynamics by the ER-resident intramembrane protease RHBDL4

P71 – Sophia N. Koerdt
The Rab27a-effector synaptotagmin-like protein 2 (Slp2) interacts with lipids to regulate Weibel-Palade body exocytosis

P72 –Daniel Kümmel
Structural and functional analysis of the Rab7/Ypt7 guanine nucleotide exchange factor Mon1-Ccz1

P73 – Claudia Matthäus
Caveolae are involved in lipid metabolism

P74 – Morten S. Nielsen
Trafficking of recycling and retrograde transported receptor in primary brain endothelial cells

P75 – Maria Rödiger
The role of ARFRP1 on adipocyte secretory function

P76 – Björn Schnute
Functional analysis of a lysine free Drosophila Notch receptor

P77 – Jörn Michael Völker
Functional analysis of pathogenic GOSR2 mutations, which are associated with progressive myoclonus epilepsies, using the yeast orthologue Bos1p

Other P78 – P92

Gene Editing
P78  – Laura Brandenstein
The challenge to insert Costello syndrome specific HRAS mutations into human keratinocytes using the CRISPR/Cas9 editing technology

Nuclear Trafficking
P79 – Lea Cochius
Muskelin`s nuclear translocation and its impact on c-Fos and p21 protein levels

Membrane Protein Biogenesis
P80 – Akos Farkas, Anne Clancy
Dissecting the in-vivo functions and client spectrum of the GET pathway

Lipid Metabolism
P81 – Alexander W. Fischer
Unravelling the mechanism and importance of BAT whole lipoprotein uptake

Membrane Trafficking
P82 – Evdokia Giannopoulou
Structural insight into protein import through peroxisomal membranes

Endolysosomal Degradation
P83 – Eugene Jennifer Jin, Ferdi Ridvan Kiral
Live observation of two parallel endomembrane degradation pathways at axon terminals

Organelle Tracking
P84 – Sergei Klykov
Time matters: tracking organelle-organelle interactions in living cells

P85 – Susanne Krasemann
Phagocytosis of apoptotic cells induces a proinflammatory program in microglia

Microtubulue Dynamics
P86 – Franco Lombino
Genetic depletion of the catalytic subunit of katanin, p60

Microtubulue Dynamics
P87 – André Lopes
Spastin regulates microtubule dynamics and is required for normal motor and cognitive functions

Autism Spectrum Disorders
P88 –  Victoria Martens
SHANK3 structure reveals a ras-association domain regulating integrin activation in neurons

Ion Channel Trafficking
P89 – Julia Menzel
Phosphorylation dependent trafficking of TASK channels

Prion Protein
P90 – Behnam Mohammadi
Neuroprotective effects of soluble N-terminal fragments of the prion protein against toxic oligomers

P91 – Liliana Rojas-Charry
Mitochondrial Form and Function in Neurons, Multifaceted Roles of Presenilin 1 in Neurodegeneration

P92 – David Wasilewski
A modified astrocyte-neuron co-culture system to model non-cell autonomous effects on synaptotoxicity and neurotoxicity in the Alzheimer’s disease